N3C Domain Teams

N3C Domain Teams enable researchers with shared interests analyze data within the N3C Data Enclave and collaborate more efficiently in a team science environment. These teams provide an opportunity to collect pilot data for grant submissions, train algorithms on larger datasets, inform clinical trial design, learn how to use tools for large scale COVID-19 data, and validate results. Domain Teams are enabled by Slack channels for discussion, meetings, and document management and are supported by N3C workstreams. N3C encourages researchers of all levels to join a Domain Team that represents their interests, or to suggest new clinical areas to explore. A Domain Team can submit one or more research projects, but collaboration is encouraged for similar concepts.

Types of Domain Teams

Multi-discipline Clinical Domain Teams focus on clinical questions surrounding COVID-19's impact on health conditions and consist of clinical and subject matter experts, statisticians, informaticists, and machine learning specialists. Cross-Cutting Domain Teams have a varied focus that applies to multiple domains.

Start a Domain Team Domain Team Support

To get started with N3C and gain access to the N3C Data Enclave, please view the Researcher Essentials webpage.

Domain Team Testimonial

Clinical Domain Teams

Acute Kidney Injury (AKI)

The Acute Kidney Injury (AKI) Clinical Domain Team aims to investigate risk factors associated with kidney injury and recovery, as well as use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in relation to COVID-19.

COVID-19 Vaccination

The goal of this Domain Team is to study the impact of vaccinations for combating the COVID-19 pandemic.

Cardiovascular Disease

The mission of the Cardiovascular Disease Clinical Domain Team is to better understand the effects of COVID-19 on patients with new and existing cardiovascular disease.

Critical Care, Ventilation, Multi-organ Dysfunction Syndrome (MODS)

The Critical Care/Ventilation/Multi-organ Dysfunction Syndrome (MODS) Clinical Domain Team aims to define and characterize the phenotypes of multiple organ dysfunction and complex disease trajectories among hospitalized patients with COVID-19.

Diabetes & Obesity

The Diabetes and Obesity Clinical Domain Team aims to address questions regarding who among people with diabetes and/or obesity are likely to experience poor outcomes in the setting of COVID-19.

Elder Impact

The Elder Impact Clinical Domain Team aims to complete a descriptive study to illustrate the impacts of COVID-19 on older adults and those with dementia/functional limitations.

Emergency Services or Medicine

The Emergency Services or Medicine Clinical Domain Team aims to study (1) the characterization of change in ED visit patterns and impact on high-risk patient populations and (2) the change in ED case mix due to quarantine.

Environmental Health

The Environmental Health Domain Team aims to study and understand the impact of environmental exposures on post-acute sequelae of COVID (PASC), also known as Long COVID, and other COVID-19 phenotypes.

Gastroenterology and Hepatology (GI/Liver)

The Gastroenterology and Hepatology Domain Team aims to gain a better understanding of how SARS-Cov-2 infection affects patient populations with chronic gastrointestinal and liver diseases.

Hematology

The goal of the Hematology Domain Team is to use the N3C Data Enclave to characterize the epidemiology, outcomes, and severity of COVID-19 in patients with a broad spectrum of hematological diseases.

Imaging

The Imaging Domain Team seeks to explore the knowledge that can be gained about the relationship between radiological imaging features and COVID-19 as well as to identify and better understand what variables in this space can be used to predict disease and outcome characteristics.

Immunosuppressed or Compromised (ISC)

The Immunosuppressed/Compromised (ISC) Clinical Domain Team aims to gain a better understanding of how COVID-19 affects patient populations with suppressed or compromised immune systems.

Long COVID

This project aims to define and characterize patients with long-term sequelae of SARS-CoV-2 infection.

Musculoskeletal (MSK)

The Musculoskeletal Clinical Domain Team aims to characterize musculoskeletal (MSK) symptoms in acute and long-COVID-19.

Neurology

The Neurology Clinical Domain Team will explore associations between COVID-19 and neurological disease, including associated neurologic symptoms and disease-related neurologic outcomes.

Oncology

The Oncology Clinical Domain Team is studying outcomes of cancer patients who contract COVID-19.

Pain, Substance Use Disorder, and Behavioral Health

The Pain, Substance Use Disorder, and Behavioral Health team aims to answer questions regarding the impact of COVID-19 on pain, substance use, and mood.

Pediatrics

The Pediatrics Clinical Domain Team aims to study the unique impact of COVID-19 on children from birth to young adulthood.

Perioperative

The Perioperative Domain Team is focused on understanding the impact of COVID-19 on the treatment and outcomes of surgical patients.

Pharmacoepidemiology

The goal of the Pharmacoepidemiology Clinical Domain Team is to evaluate important, empirically testable hypotheses regarding the use, safety, and effectiveness of therapies for COVID-19 using a limited dataset from the N3C.

Pregnancy

The Pregnancy Clinical Domain Team aims to leverage N3C data to gain insights into pressing COVID-19 questions around pregnancy.

Rural Health

The Rural Health Domain Team seeks to understand the epidemiology, utilization, treatment, and outcomes of the COVID-19 pandemic in rural communities. The overarching goal is to develop better evidence for potential differences in the COVID-19 epidemic response and outcomes for rural health care centers and rural dwellers.

Sleep

The goal of the Sleep Domain Team is to support the design and execution of studies that are leveraging sleep disorders and related phenotypes.

Social Determinants of Health (SDoH)

The goal of the Social Determinants of Health (SDoH) Clinical Domain Team is to identify at least three questions that either validate current research or answer new questions for the following categories: local policy around COVID-19, impact of groups experiencing resource challenges, and impact of the pandemic on inequalities.