Clinical Domain Teams

N3C Domain Teams enable researchers with shared interests analyze data within the N3C Data Enclave and collaborate more efficiently in a team science environment. These teams provide an opportunity to collect pilot data for grant submissions, train algorithms on larger datasets, and learn how to use tools for large scale COVID-19 data. Domain Teams are enabled by Slack channels for discussion, meetings, and document management and are supported by N3C workstreams. N3C encourages researchers of all levels to join a Domain Team that represents their interests, or to suggest new clinical areas to explore. A Domain Team can submit one or more research projects, but collaboration is encouraged for similar concepts.

Types of Domain Teams

Multi-discipline Clinical Domain Teams consisting of clinical and subject matter experts, statisticians, informaticists, and machine learning specialists focus on clinical questions surrounding COVID-19's impact on health conditions, whereas Cross-Cutting Domain Teams have a varied focus that applies to multiple domains.

For questions or comments, please access the N3C Support Desk and click on "Request Domain Team Support".

To get started with N3C and gain access to the N3C Data Enclave, please view the Researcher Essentials webpage.

Domain Team Testimonial

Clinical Domain Teams

Acute Kidney Injury (AKI)

The Acute Kidney Injury (AKI) Clinical Domain Team aims to investigate risk factors associated with kidney injury and recovery, as well as use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in relation to COVID-19.


The Cardiology Clinical Domain Team will explore issues related to cardiology and COVID-19.

Diabetes & Obesity

The Diabetes and Obesity Clinical Domain Team aims to address questions regarding who among people with diabetes and/or obesity are likely to experience poor outcomes in the setting of COVID-19.

Elder Impact

The Elder Impact Clinical Domain Team aims to complete a descriptive study to illustrate the impacts of COVID-19 on older adults and those with dementia/functional limitations.

Emergency Services or Medicine

The Emergency Services or Medicine Clinical Domain Team aims to study (1) the characterization of change in ED visit patterns and impact on high-risk patient populations and (2) the change in ED case mix due to quarantine.

Immunosuppressed or Compromised (ISC)

The Immunosuppressed/Compromised (ISC) Clinical Domain Team aims to gain a better understanding of how COVID-19 affects patient populations with suppressed or compromised immune systems.


The Neurology Clinical Domain Team will explore issues related to neurology and COVID-19.


The Oncology Clinical Domain Team is studying the outcomes of COVID-19 infected patients who also suffer from cancer.


The Pediatrics Clinical Domain Team aims to study the unique impact of COVID-19 on children from birth to young adulthood.


The goal of the Pharmacoepidemiology Clinical Domain Team is to evaluate important, empirically testable hypotheses regarding the use, safety, and effectiveness of therapies for COVID-19 using a limited dataset from the N3C.


The Pregnancy Clinical Domain Team aims to leverage N3C data to gain insights into pressing COVID-19 questions around pregnancy.

Short & Long-term Complications

The Short and Long Term Complications Clinical Domain Team seeks to better understand complications resulting from COVID-19 in all patient populations.

Social Determinants of Health (SDoH)

The goal of the Social Determinants of Health (SDoH) Clinical Domain Team is to identify at least three questions that either validate current research or answer new questions for the following categories: local policy around COVID-19, impact of groups experiencing resource challenges, and impact of the pandemic on inequalities.

Cross-Cutting Domain Teams

Applicable Data Methods & Standards (ADM&S)

The Applicable Data Methods & Standards (ADM&S) Domain Team aims to explore which data methods & standards are applicable to the range of questions researchers will pursue within N3C.


The Genomics Domain Team will explore issues related to genomics and COVID-19.


The Human Phenotype Ontology (HPO)-OMOP Domain Team will explore the use of the HPO and the OMOP common data model for COVID-19 data research.


The Imaging Domain Team seeks to explore the knowledge that can be gained about the relationship between radiological imaging features and COVID-19 as well as to identify and better understand what variables in this space can be used to predict disease and outcome characteristics.

Machine Learning (ML)

The purpose of the Machine Learning (ML) Domain Team is to develop code and documentation to illustrate ML best practices in the N3C Data Enclave and to collaborate on selected ML topics.

Pharma - Commercial

The vision of the Pharma-Commercial Domain Team is to maximize engagement with commercial groups to support the increased use and utility of N3C resources and community for research on COVID-19.

Rural Health

The Rural Health Domain Team seeks to understand the epidemiology, utilization, treatment, and outcomes of the COVID-19 pandemic in rural communities. The overarching goal is to develop better evidence for potential differences in the COVID-19 epidemic response and outcomes for rural health care centers and rural dwellers.

Domain Team Meetings Calendar