Immunosuppressed or Compromised (ISC)


The Immunosuppressed/Compromised (ISC) Clinical Domain Team aims to gain a better understanding of how COVID-19 affects patient populations with suppressed or compromised immune systems. The initial research will focus on a subset of target populations, including persons with HIV, solid organ transplant patients, and patients with autoimmune disorders, including skin diseases such as atopic dermatitis and eczema. The team will also identify areas of research for the ISC populations that will require additional in-depth study at a level that the N3C data may not be able to provide. Through this research, a better understanding will be gained for how various types, levels, and durations of immunosuppression or compromise contribute towards ISC patient outcomes upon COVID-19 infection.



First Time Users: To get started with N3C and gain access to the N3C Data Enclave, please view the Researcher Essentials webpage.
For Questions or Comments: Please access the N3C Support Desk and click on "Request Domain Team Support".

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Amy Olex, MS Headshot

Virginia Commonwealth University

Roslyn Mannon, MD_cropped

University of Nebraska Medical Center

Vithal Madhira Headshot
Vithal Madhira