Immunosuppressed or Compromised (ISC)


The Immunosuppressed/Compromised (ISC) Clinical Domain Team aims to gain a better understanding of how COVID-19 affects patient populations with suppressed or compromised immune systems. The initial research will focus on a subset of target populations, including persons with HIV, solid organ transplant patients, and patients with autoimmune disorders, including skin diseases such as atopic dermatitis and eczema. The team will also identify areas of research for the ISC populations that will require additional in-depth study at a level that the N3C data may not be able to provide. Through this research, a better understanding will be gained for how various types, levels, and durations of immunosuppression or compromise contribute towards ISC patient outcomes upon COVID-19 infection.

Team meetings are held on the 2nd Thursday of the month at 7:00am PT/10:00am ET. Register for meetings here.

The Immunosuppressed/Compromised (ISC) Domain Team is comprised of several self-organizing subdomain teams that lead research in their specific specialties and projects. These teams focus on researching the impact of COVID-19 on particular subsets of the ISC population. For more information on the ISC Domain Team, their work within the N3C Data Enclave, and their associated subdomain teams, view the recorded ISC presentations.


(Manuscripts for each conference presentation are in progress and will be displayed when published.)

Racial Disparities in COVID-19 Positivity Among People Living with HIV in the US Islam JY, Madhira V, Sun J, Olex AL, Kirk GD, Franceschini N, Patel R.

COVID-19 Hospitalization among People with HIV or Solid Organ transplant in the U.S (Conference on Retroviruses and Opportunistic Infections, 2021) Sun J, Patel R., Madhira V, Olex A, French E, Islam J, Moffitt R, Franceschini N, Mannon, R, Kirk G.

COVID-19 In Solid Organ Transplantation (SOT): Results of the National Covid Cohort Collaborative (N3C) (Cutting Edge of Transplant Conference, 2021) Vinson AJ, Agarwal G, Dal R, French E, Lee S, Olex A, Anzalone A, Madhira V, Mannon R.

COVID-19 In Solid Organ Transplantation (SOT): Results of the National Covid Cohort Collaborative (N3C) (American Transplant Congress, 2021) Agarwal G, Vinson A, Dai R, French E, Lee S, Olex A, Anzalone A, Madhira V, Mannon RB.

Lead Contact

Amy L. Olex, PhD

Senior Bioinformatics Specialist:
C. Kenneth and Dianne Wright Center for Clinical and Translational Research

Virginia Commonwealth University




First Time Users: To get started with N3C and gain access to the N3C Data Enclave, please view the Researcher Essentials webpage.
For Questions or Comments: Please access the N3C Support Desk and click on "Request Domain Team Support".

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Amy Olex, PhD Headshot

Virginia Commonwealth University

Rena Patel Headshot

University of Washington Medicine