National COVID Cohort Collaborative (N3C) Workstreams

The COVID-19 global emergency raises many difficult care and healthcare management questions. Which drugs are the most viable candidates for a given patient? How can we efficiently and effectively assemble the right cohort for a trial? What social determinants impact course and outcome? How can we rapidly deploy clinical decision support tools when new knowledge is available every day?

By leveraging our collective data resources, unparalleled analytics expertise, and medical insights from expert clinicians, we can synergize discoveries that address this pandemic beyond the sum of our parts. The National COVID Cohort Collaborative (N3C) is a collaboration among the NCATS-supported Clinical and Translational Science Awards (CTSA) Program hubs, the National Center for Data to Health (CD2H), distributed clinical data networks (PCORnet, OHDSI, ACT, TriNetX), and other partner organizations, with overall stewardship by NIH’s National Center for Advancing Translational Sciences (NCATS). The N3C aims to improve the efficiency and accessibility of analyses with COVID-19 clinical data, expand our ability to analyze and understand COVID, and demonstrate a novel approach for collaborative pandemic data sharing.

What the N3C is building:

An EHR-based limited data set of COVID-19 patients and controls for row-level data access
A secure, FedRAMP-compliant analytical environment where tools and algorithms can be rapidly evaluated, and clinicians and researchers can ask granular and complex clinical questions
A resource that is complementary and synergistic with individual institutional and consortial activities
A place for data harmonization, mapping, and curation driven by the Center for Data to Health (CD2H)
A vehicle for stewardship coordinated and supported by NCATS

N3C Partnership Webinar

Learn more from our N3C Partnership Webinar (5/15/20). View slides.

The coronavirus pandemic presents a unique opportunity to bring together top informatics experts from around the country to address our collective challenges. The N3C resource offers a valuable contribution, not only for aiding the COVID-19 crisis, but for transforming how we perform research as a nation.

View slide deck from the NIAID Data Science Series webinar: Realizing the National COVID Cohort Collaborative (N3C) 5/15/2020.

Workstreams

N3C Events

View N3C Calendar

To Cite the N3C: "The analyses described in this [publication/report/presentation] were conducted with data or tools accessed through the NCATS N3C Data Enclave https://covid.cd2h.org and N3C Attribution & Publication Policy v 1.2-2020-08-25b supported by NCATS Contract No. 75N95023D00001 and [insert additional funding agencies or sources and reference numbers as declared by the contributors in their form response above]. This research was possible because of the patients whose information is included within the data and the organizations (https://ncats.nih.gov/n3c/resources/data-contribution/data-transfer-agreement-signatories) and scientists who have contributed to the on-going development of this community resource [https://doi.org/10.1093/jamia/ocaa196]."

For publication submission information, please see the Publication Review Page