Researcher Essentials

Data Enclave Access
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Domain Teams
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Governance Documents
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DUA Signatories
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Join the Effort

Register for access to the N3C Data Enclave and explore harmonized clinical data within a secure analytics platform.

Researchers are welcome to request access to the N3C Data Enclave, one of the largest, most secure clinical data resources for accelerating and collaborating on COVID-19 research. Users may also join or start an N3C Domain Team to help coordinate work with others. If you experience difficulty at any stage in your enclave journey, please visit the N3C Support Desk.

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Gain Access to the Enclave

1) Complete the Enclave Registration Checklist to expedite your N3C Data Enclave account creation.

2) Follow the Enclave Registration Instructions to request and access your enclave account.

  • During the process of creating your enclave account, you will also complete your N3C registration. You can update your profile information anytime here.

Clinical Domain Teams

N3C Clinical Domain Teams enable researchers with shared interests to analyze data within the N3C Data Enclave more efficiently and to collaborate on multi-site research. The Clinical Domain Teams, developed within the Clinical Scenarios subgroup, focus on specific clinical questions surrounding COVID-19's impact on health conditions. Clinical Domain Teams are enabled by Slack channels for discussion, meetings, and document management, and are supported by N3C workstreams and administration. N3C encourages researchers of all levels to join a Domain Team that represents their interests, or to suggest new clinical areas to explore.

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Required Governance Documents

  • The Data Use Agreement (DUA) is a legal document that covers the terms of how data are accessed or used within the N3C Data Enclave. It is executed between NCATS and a research institution (or directly with a researcher in the case of an individual citizen scientist who is not affiliated with an institution). This agreement covers the contributing site’s use of the data for research. Signing of the DUA and IRB approval are both required to use data in the N3C Data Enclave.
  • A Data Use Request (DUR) is an online application submitted within the N3C Data Enclave by the researcher to describe the scope and nature of their work and to justify the data access tier they are requesting. Approved DURs are valid for 1 year and are renewable. Learn more about the Data Use Request (DUR) process here.