N3C Registration Checklist

✔ Confirm that an executed Data Use Agreement (DUA) exists between your organization and NCATS. Check the DUA Signatories List here

• If your institution does not have a signed DUA, access a copy of the DUA to be signed by your institution and email it to NCATSPartnerships@mail.nih.gov for counter-signature by NCATS.

✔ Completion of NIH Information Security and Information Management Training

• Each individual data user must complete the Information Security and Management Refresher, which consists of 6 modules (Information Security, Insider Threats, Privacy Awareness, Records Management, Emergency Preparedness, Rules of Behavior).
• After completing the 6th module of the Information Security and Management Refresher course (only), a button will appear on the top bar that says "Print Certificate".

✔ Documentation of completion of Human Subjects Research Protection training in alignment with your institution's policies if you intend to access the de-identified or limited datasets. (This training requirement does not apply to investigators who will only access the synthetic dataset.)

• Users will be asked to provide the date the training was completed, and retain evidence of completion to provide NCATS upon request.
• NIH Required Education in the Protection of Human Research Participants or CITI Program courses may be used to complete your required training; consult your Human Research Protection Program (HRPP) for your institution's specific requirements.

Data Use Request (DUR)

NOTE: Data access requirements may change over time.

✔ To fill out the electronic Data Use Request (DUR) form within the Enclave, you will be asked to provide the following:

• Sufficient information for the Data Access Committee (DAC) to understand the proposed research project and analyses
• Rationale for the requested level of access needed to conduct the proposed work
• A generalized outline of anticipated analysis

✔ If requesting access to the limited dataset, a copy of your institution’s Human Research Protection Program (HRPP) IRB determination letter must be available for uploading.

Account Creation

✔ Institutional email address

✔ A smartphone or tablet

✔ Downloaded two-factor authentication app

• System will offer apps, such as DUO, Free OTP, Google Authenticator, and Microsoft Authenticator.

✔ ORCID ID is required to access the N3C Data Enclave and is used to provide author attribution. Create an ORCID ID account, here.

• Account creation is free and quick.

If you experience difficulty with any of these steps, please visit the N3C Support Desk.