COVID Case Report Forms, Standards, and Protocols
Inventory of COVID Case Report Forms (CRFs) & Phenotyping Standards
Below is a list of known CRFs for triage, intake, and patient-focused phenotype/metadata collection efforts. This inventory is intended primarily for knowledge exchange, with the aim of creating a computable standard for phenotype data sharing. Additional entries welcome.
University of Pennsylvania
University of Pennsylvania coordinated with multiple CTSAs to develop a Case Report Form and its accompanying REDCap data dictionary. Contributors: Columbia, Harvard, UT Southwestern, University of Washington, University of Pittsburgh, UCLA, UCSD, University of Kansas, and USC
Columbia University developed a Case Report form already in use. It is being translated into Spanish, Italian, German, French, Polish, Japanese, Chinese, and Korean.
CDISC is developing an Interim User Guide for COVID-19 with WHO, CDC, FDA including Study Data Tabulation Model (SDTM) domains, variables, and Controlled Terminology. CRFs are then based on and align with these specifications. The controlled Terminology is in NCIt, includes cross NIH IC CDEs.
See especially signs and symptoms.
The Virus Outbreak Data Network (VODAN) of GO FAIR has several projects. The first project within this implementation network aims at making the clinical/screening data collection based on the WHO case record form (CRF) for Corona ("rapid" version) FAIR for both humans and machines. A semantic data model representing this CRF was also just launched. URI
COVID-19 Collaboration Platform
CovidCP aims to publicize protocols from PIs that are open to collaboration: joining forces with other research teams to create a core protocol; admitting new sites under the existing PI and IRB; sharing anonymized interim and/or final data through Vivli with other sites that choose to independently operate a trial under a similar protocol.