The Critical Care/Ventilation/Multi-organ Dysfunction Syndrome (MODS) Clinical Domain Team, one of few “joint” N3C Domain Teams, aims to better understand and characterize complex disease trajectories including multiple organ dysfunction, along with determination of treatment efficacies to improve outcomes in critically ill patients with COVID-19. The vision of the Critical Care/Ventilation/MODS Domain Team is to understand the pathophysiology of the SARS-CoV-2 virus on single and multi-organ systems, and what determines optimal treatment strategies affecting short- and longer-term outcomes of critically ill COVID-19 patients. The ventilation subgroup is focused on defining critical care cohorts based on ventilation strategies, as well as studying clinical outcomes on intubated patients versus those not intubated. The MODS subgroup focuses on characterizing multi-organ dysfunction as a temporal trajectory and probabilistic process.
Both subgroups are actively soliciting members to join and contribute to the goals and mission of this highly unique domain team.