Collaborative Analytics Workstream


Build a secure enclave and collaborative portal for deployment of machine learning and other analytical tools and methods to address key clinical and translational questions. Work collaboratively to generate insights related to COVID-19 from the harmonized limited data set. Experts in artificial intelligence (AI), machine learning (ML), and other technologies assist with review and portal architecture iteration to ensure fit-for-purpose implementation.


Register for Meetings
Mondays 2:00 pm PT/5:00 pm ET

Join a Domain Team

N3C Domain Teams, developed within the Clinical Scenarios subgroup, enable researchers with shared clinical questions surrounding COVID-19 to collectively analyze data within the N3C Data Enclave and collaborate more efficiently in a team science environment. These teams provide an opportunity to collect pilot data for grant submissions, train algorithms on larger datasets, and learn how to use tools for large-scale COVID-19 data.

Join a Domain Team

Connect with Us:

  1. Onboard to N3C using the link below.
    • In there you will provide your email address. We will add that email address to the CD2H workspace.
  2. Go to our workstream Slack channel directly using the link provided below.
    • Login with your Slack credentials.
Collaborative Analytics Workstream Icon


Data in the N3C Data Enclave are secured to the highest standards as mandated by applicable NIH policy. All data are encrypted both in transit and at rest, without exception. In transit, data traffic is encrypted via SSL/TLS during both client-to-server and server-to-server communication. The software implements permissions to access or edit data as a granular dataset or row-level depending on the level of data access agreed upon by the Lead Investigator and the Data Access Committee (DAC). These permissions flow through the Enclave as derived data, analytics, or reports from the underlying secure fields to ensure all data are secure at all stages of storage and processing. Please see the NCATS N3C webpage for more detailed information.

Yes; the N3C Data Enclave supports comprehensive auditing of all significant data processing and access events. It captures metadata about the source of the data. It also maintains records of data imports, reads, writes, exports, and deletions along with the user, time, date, and action. This metadata can be used to track revision history and manage compliance with data auditing and oversight requirements. As standard practice, audited items include:

  • Import and export of data
  • User access (‘reading’) of data
  • User edits of data
  • Change to dataset permissions
  • Granting or revoking of user roles or privileges
  • User logging into the Enclave
  • Failed login attempts

Leadership and Administration

Joel Saltz Headshot

Stony Brook University

Workstream Lead
Usman Sheikh Headshot
Usman Sheikh


Project Manager
Rafael Fuentes Headshot
Rafael Fuentes


Project Manager


Facilitate the creation of clinical and methodologic domain teams, and the identification and creation of COVID-19 focused data elements and core analytic workflows.

Heidi Spratt (University of Texas Medical Branch) and Melissa Haendel (University of Colorado)

Alternating Mondays 9:00 am PT/12:00 pm ET Register Here

Leverage existing efforts across consortia to create comprehensive data extraction for COVID-19 research. View a recording describing the building of the N3C NLP infrastructure.

Office Hours: Every other Thursday 12pm PT / 3pm ET beginning January 6th, 2022.  Sign up for office hours.

NLP Wiki: Access the link.


NLPSandbox Blog Post

Hongfang Liu (Mayo Clinic), Hua Xu (UTH), Peter Szolovits (MIT)

Thursdays 12pm PT/3pm ET Register Here

Develop curated data elements around COVID-19 outcomes and progression, and organize data to facilitate analyses involving temporal evolution.

Dave Eichmann (University of Iowa), Warren Kibbe (Duke University)

Tuesdays 10:00 am PT/1:00 pm ET Register Here

Develop and deploy analytic tools and resources driven by clinical scenarios, including analytic tools for clinical data, knowledge graphs, and for clinical data linked to knowledge graphs.

Andrew Williams (Tufts University), Chunlei Wu (Scripps Research Institute)

Fridays 1:00 pm PT/4:00 pm ET Register Here